Next generation sequencing (NGS) combined with bioinformatics has successfully been
used in a vast array of analyses for infectious disease research of public health relevance …

The patterns and processes of influenza virus evolution are of fundamental importance,
underpinning such traits as the propensity to emerge in new host species and the ability to …

Influenza A virus (IAV) continues to pose an enormous and unpredictable global public
health threat, largely due to the continual evolution of escape from preexisting immunity and …

Highlights•Multipartite and segmented viruses are members of∼ 11% of classified virus
genera.•Segmented viruses with semi-infectious particles have higher propensity to …

Reassortment, which is the exchange of genome sequence between viruses co-infecting a
host cell, plays an important role in the evolution of segmented viruses. In the human …

Background Non-targeted whole genome sequencing is a powerful tool to comprehensively
identify constituents of microbial communities in a sample. There is no need to direct the …

Suboptimal vaccine effectiveness against seasonal influenza is a significant public health
concern, partly explained by antigenic differences between vaccine viruses and viruses …

The role of sub-Saharan Africa in the global spread of influenza viruses remains unclear due
to insufficient spatiotemporal sequence data. Here, we analyzed 222 codon-complete …

Seasonal influenza epidemics are associated with high mortality and morbidity in the human
population. Influenza surveillance is critical for providing information to national influenza …

Thorough molecular characterization of reference viruses supports the detection of
emerging human pathogens as well as studies of evolutionary relationships. However, full …