Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Obesity is a multifaceted chronic condition with several contributing causes, including
biological risk factors, socioeconomic status, health literacy, and numerous environmental …

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the
hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in …

The fruit fly can evaluate its energy state and decide whether to pursue food-related cues.
Here, we reveal that the mushroom body (MB) integrates hunger and satiety signals to …

Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in
regulating a variety of biological processes, including food intake, energy metabolism, and …

The brain has been traditionally thought to be insensitive to insulin, primarily because
insulin does not stimulate glucose uptake/metabolism in the brain (as it does in classic …

Ovulatory disorders are the most common clinical feature exhibited among obese women.
Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone …

In numerous brain structures, insulin signaling modulates the homeostatic processes,
sensitivity to reward pathways, executive function, memory, and cognition. Through human …

Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …