The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

DNA oxidation and excision repair pathways

TH Lee, TH Kang - International journal of molecular sciences, 2019 - mdpi.com
The physiological impact of the aberrant oxidation products on genomic DNA were
demonstrated by embryonic lethality or the cancer susceptibility and/or neurological …

Contributions of DNA damage to Alzheimer's disease

X Lin, A Kapoor, Y Gu, MJ Chow, J Peng… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Its typical
pathology consists of extracellular amyloid-β (Aβ) plaques and intracellular tau …

[HTML][HTML] Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of …

X Ren, D Boriero, L Chaiswing, S Bondada… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Increasing numbers of cancer patients survive and live longer than five years after therapy,
but very often side effects of cancer treatment arise at same time. One of the side effects …

Mitostasis, calcium and free radicals in health, aging and neurodegeneration

JA Godoy, JA Rios, P Picón-Pagès… - Biomolecules, 2021 - mdpi.com
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …

Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts

RF Itzhaki - The FASEB Journal, 2017 - Wiley Online Library
Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains
of apolipoprotein E‐«4 carriers, is a major risk for Alzheimer's disease (AD) is increasing …

Exploring the causal relationship between telomere biology and Alzheimer's disease

XY Kuan, NSA Fauzi, KY Ng, A Bakhtiar - Molecular Neurobiology, 2023 - Springer
Telomeres, also known as the “protective caps” of our chromosomes, shorten with each cell
cycle due to the end replication problem. This process, termed telomere attrition, is …

DNA double-strand break accumulation in Alzheimer's disease: evidence from experimental models and postmortem human brains

N Thadathil, DF Delotterie, J Xiao, R Hori… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for a
majority of dementia cases. AD is characterized by progressive neuronal death associated …

MicroRNAs as potential orchestrators of Alzheimer's disease-related pathologies: insights on current status and future possibilities

NZ Abuelezz, FE Nasr, MA AbdulKader… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …