Respiratory microbiome and epithelial interactions shape immunity in the lungs

R Invernizzi, CM Lloyd, PL Molyneaux - Immunology, 2020 - Wiley Online Library
The airway epithelium represents a physical barrier to the external environment acting as
the first line of defence against potentially harmful environmental stimuli including microbes …

Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

E Conte - Pharmacology & Therapeutics, 2022 - Elsevier
Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Comparative analysis of the alveolar microbiome in COPD, ECOPD, Sarcoidosis, and ILD patients to identify respiratory illnesses specific microbial signatures

S Gupta, M Shariff, G Chaturvedi, A Sharma, N Goel… - Scientific Reports, 2021 - nature.com
Studying respiratory illness-specific microbial signatures and their interaction with other
micro-residents could provide a better understanding of lung microbial ecology. Each …

The lung microbiome: clinical and therapeutic implications

A Fabbrizzi, A Amedei, F Lavorini, T Renda… - Internal and emergency …, 2019 - Springer
The human respiratory tract, usually considered sterile, is currently being investigated for
human-associated microbial communities. According to Dickson's conceptual model, the …

Gram‐negative microbiota is related to acute exacerbation in children with asthma

YH Kim, H Jang, SY Kim, JH Jung… - Clinical and …, 2021 - Wiley Online Library
Background The upper‐airway microbiota may be associated with the pathogenesis of
asthma and useful for predicting acute exacerbation. However, the relationship between the …

Low IgA associated with oropharyngeal microbiota changes and lung disease in primary antibody deficiency

RM Berbers, FAA Mohamed Hoesein… - Frontiers in …, 2020 - frontiersin.org
Common Variable Immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are
primary antibody deficiencies characterized by hypogammaglobulinemia and recurrent …

Exploring the role of respiratory microbiome in lung cancer: A systematic review

F Perrone, L Belluomini, M Mazzotta, M Bianconi… - Critical Reviews in …, 2021 - Elsevier
Giving the potential contribute in cancer initiation and progression, lung microbiota
represents a promising topic in cancer research, although still unexplored. We performed a …

The microbiome in the lower respiratory tract

K Yatera, S Noguchi, H Mukae - Respiratory investigation, 2018 - Elsevier
With the advent of new technologies evaluating the microbiome in the sample such as next-
generation sequencer (NGS), current increase of an interest in understanding of the lung …

Long-read sequencing based clinical metagenomics for the detection and confirmation of Pneumocystis jirovecii directly from clinical specimens: A paradigm shift in …

L Irinyi, Y Hu, MTV Hoang, L Pasic, C Halliday… - Medical …, 2020 - academic.oup.com
The advent of next generation sequencing technologies has enabled the characterization of
the genetic content of entire communities of organisms, including those in clinical …

The human microbiome: A promising target for lung cancer treatment

Y Sun, M Wen, Y Liu, Y Wang, P Jing, Z Gu… - Frontiers in …, 2023 - frontiersin.org
Lung cancer is the leading cause of cancer-related deaths worldwide, and insights into its
underlying mechanisms as well as potential therapeutic strategies are urgently needed. The …