Dysregulated lipid metabolism links NAFLD to cardiovascular disease

A Deprince, JT Haas, B Staels - Molecular metabolism, 2020 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming a global health
problem. Cardiovascular diseases (CVD) are the most common cause of mortality in NAFLD …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease

ME Rinella, BA Neuschwander-Tetri, MS Siddiqui… - Hepatology, 2023 - journals.lww.com
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AI, artificial
intelligence; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUROC …

[PDF][PDF] Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD

ME Rinella, F Tacke, AJ Sanyal, QM Anstee… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a global public health concern. Its natural history,
the development of nonalcoholic steatohepatitis (NASH) and fibrosis, is highly variable …

NAFLD, and cardiovascular and cardiac diseases: Factors influencing risk, prediction and treatment

G Targher, KE Corey, CD Byrne - Diabetes & metabolism, 2021 - Elsevier
Background and aim Non-alcoholic fatty liver disease (NAFLD), affecting up to around 30%
of the world's adult population, causes considerable liver-related and extrahepatic morbidity …

Advances in the diagnosis and treatment of non-alcoholic fatty liver disease

X Yin, X Guo, Z Liu, J Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that
affects approximately one-quarter of the global adult population, posing a significant threat …

Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease

A Fougerat, A Montagner, N Loiseau, H Guillou… - Cells, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, frequently
associated with obesity and type 2 diabetes. Steatosis is the initial stage of the disease …

New drugs for NAFLD: lessons from basic models to the clinic

KC Reimer, A Wree, C Roderburg, F Tacke - Hepatology international, 2020 - Springer
The term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly
harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic …

An update on the current and emerging use of thiazolidinediones for type 2 diabetes

RV Giglio, N Papanas, AA Rizvi, M Ciaccio, AM Patti… - Medicina, 2022 - mdpi.com
Guidelines have increasingly stressed the concept that adequate glycemic control is
required to prevent or decrease the macro-and microvascular complications of type 2 …

Prevalence and predictors of non-alcoholic steatohepatitis in subjects with morbid obesity and with or without type 2 diabetes

E Lembo, MF Russo, O Verrastro, D Anello… - Diabetes & …, 2022 - Elsevier
Aim To investigate the prevalence of biopsy-proven non-alcoholic steatohepatitis (NASH) in
a cohort of patients with morbid obesity and with or without type 2 diabetes (T2D) and to find …