Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential
Hepatitis B virus (HBV) infection remains a major public health concern worldwide with
about 257 million individuals chronically infected. Current therapies can effectively control …
about 257 million individuals chronically infected. Current therapies can effectively control …
Revisiting hepatitis B virus: challenges of curative therapies
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …
A global scientific strategy to cure hepatitis B
PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019 - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
Global burden of NAFLD and chronic liver disease among adolescents and young adults
JM Paik, K Kabbara, KE Eberly, Y Younossi, L Henry… - Hepatology, 2022 - journals.lww.com
Conclusions HBV cccDNA minichromosomes in distinct epigenetic transcriptional states
showed a similar reduction rate during cell division but significantly differed in their …
showed a similar reduction rate during cell division but significantly differed in their …
DNA polymerase κ is a key cellular factor for the formation of covalently closed circular DNA of hepatitis B virus
Hepatitis B virus (HBV) infection of hepatocytes begins by binding to its cellular receptor
sodium taurocholate cotransporting polypeptide (NTCP), followed by the internalization of …
sodium taurocholate cotransporting polypeptide (NTCP), followed by the internalization of …
Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …
Prospects for the global elimination of hepatitis B
Chronic hepatitis B virus (HBV) infection is the leading cause of liver cirrhosis and
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
hepatocellular carcinoma, estimated to be globally responsible for∼ 800,000 deaths …
The structural biology of hepatitis B virus: form and function
B Venkatakrishnan, A Zlotnick - Annual review of virology, 2016 - annualreviews.org
Hepatitis B virus is one of the smallest human pathogens, encoded by a 3,200-bp genome
with only four open reading frames. Yet the virus shows a remarkable diversity in structural …
with only four open reading frames. Yet the virus shows a remarkable diversity in structural …
HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
polymerase into nucleocapsids for reverse transcriptional DNA replication to take place …
Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus
K Kitamura, L Que, M Shimadu, M Koura… - PLoS …, 2018 - journals.plos.org
Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …
hepatocellular carcinoma. Chronic HBV infection is a key factor in these severe liver …