Calcific aortic valve disease (CAVD) is a highly prevalent condition that comprises a disease
continuum, ranging from microscopic changes to profound fibro-calcific leaflet remodelling …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …

The continuing increase in the prevalence of diabetes mellitus in the general population is
predicted to result in a higher incidence of cardiovascular disease. Although the …

Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Aortic stenosis is a common, potentially fatal condition that is set to become an increasing
public health burden. Once symptoms develop, there is an inexorable deterioration with a …

Plaque calcification develops by the inflammation-dependent mechanisms involved in
progression and regression of atherosclerosis. Macrophages can undergo two distinct …

Calcification is a clinical marker of atherosclerosis. This review focuses on recent findings on
the association between calcification and plaque vulnerability. Calcified plaques have …