Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

Atrial dysfunction has been widely considered a marker or consequence of other cardiac
conditions rather than the cause itself. Here, we propose the term atrial failure as a clinically …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Aims Left atrial (LA) function is impaired in heart failure with preserved ejection fraction
(HFpEF) and predicts disease severity and risk of adverse outcome. We sought to evaluate …

Background: Right heart catheterization using exercise stress is the reference standard for
the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of …

Pulmonary hypertension (PH) associated with left heart disease, or Group 2 PH, includes
heart failure, valvular heart diseases, and congenital heart diseases. Although it is axiomatic …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Background—Although left atrial (LA) dysfunction is common in heart failure with preserved
ejection fraction (HFpEF), its functional implications beyond the reflection of left ventricular …

Atrial enlargement in response to pathological stimuli (eg, hypertension, mitral valve
disease) and physiological stimuli (exercise, pregnancy) can be comparable in magnitude …

Almost three-quarters of all heart failure patients who are older than 65 have heart failure
with preserved ejection fraction (HFpEF). The proportion and hospitalization rate of patients …