Scaling up cryo-EM for biology and chemistry: The journey from niche technology to mainstream method
MJ de la Cruz, ET Eng - Structure, 2023 - cell.com
Cryoelectron microscopy (cryo-EM) methods have made meaningful contributions in a wide
variety of scientific research fields. In structural biology, cryo-EM routinely elucidates …
variety of scientific research fields. In structural biology, cryo-EM routinely elucidates …
Cryo-electron microscopy-based drug design
E Cebi, J Lee, VK Subramani, N Bak, C Oh… - Frontiers in Molecular …, 2024 - frontiersin.org
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …
more potent drugs compared to conventional drug-discovery methods. The success of …
Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design
M Mukherjee, PJ Day, D Laverty, JA Bueren-Calabuig… - Structure, 2024 - cell.com
Summary Cyclin dependent kinase 7 (CDK7) is an important therapeutic kinase best known
for its dual role in cell cycle regulation and gene transcription. Here, we describe the …
for its dual role in cell cycle regulation and gene transcription. Here, we describe the …
Kinematic analysis of kinases and their oncogenic mutations–Kinases and their mutation kinematic analysis
X Chen, S Leyendecker - Molecular Informatics, 2024 - Wiley Online Library
Protein kinases are crucial cellular enzymes that facilitate the transfer of phosphates from
adenosine triphosphate (ATP) to their substrates, thereby regulating numerous cellular …
adenosine triphosphate (ATP) to their substrates, thereby regulating numerous cellular …
Finding Antibodies in Cryo-EM densities with CrAI
Therapeutic antibodies have emerged as a prominent class of new drugs due to their high
specificity and their ability to bind to several protein targets. Once an initial antibody has …
specificity and their ability to bind to several protein targets. Once an initial antibody has …