Lifestyle factors, which include the practices we adopt in our daily life, have a significant role
in shaping our overall health. These lifestyle choices are mainly centered on personal …

Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Circadian rhythms regulate a wide variety of physiological and metabolic processes. The
clock machinery comprises complex transcriptional–translational feedback loops that …

Relapse to uncontrolled use of a psychoactive substance is arguably the single most
defining characteristic of an addiction. Relapse following addiction treatment is very …

Alcohol consumption is one of the most serious substance abuse disorders worldwide.
Alcohol-related deaths, diseases, and disabilities are higher in men than women and are …

Histone acetylation and other modifications of the chromatin are important regulators of
gene expression and, consequently, may contribute to drug-induced behaviors and …

Fear conditioning is a frequently used paradigm for assessing learning and memory in
rodents. Traditionally researchers have relied upon scoring of fear-related behavior by …

Background Depression and alcohol abuse or dependence (AUD) co-occur in the general
population more frequently than expected by chance. Alcohol use influences the circadian …

Adverse life events and highly stressful environments have deleterious consequences for
mental health. Those environmental factors can potentiate alcohol and drug abuse in …

During the past decade, it has been shown that circadian clock genes have more than a
simple circadian time-keeping role. Clock genes also modulate motivational processes and …