The most competent plant-derived natural products for targeting apoptosis in cancer therapy

S Rajabi, M Maresca, AV Yumashev, R Choopani… - Biomolecules, 2021 - mdpi.com
Cancer is a challenging problem for the global health community, and its increasing burden
necessitates seeking novel and alternative therapies. Most cancers share six basic …

Neuroglobin, clues to function and mechanism

C Exertier, LC Montemiglio, I Freda, E Gugole… - Molecular Aspects of …, 2022 - Elsevier
Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family
that diverged early in evolution. Sequence conservation and presence in nervous cells of …

Molecular Interactions between Neuroglobin and Cytochrome c: Possible Mechanisms of Antiapoptotic Defense in Neuronal Cells

MA Semenova, RV Chertkova, MP Kirpichnikov… - Biomolecules, 2023 - mdpi.com
Neuroglobin, which is a heme protein from the globin family that is predominantly expressed
in nervous tissue, can promote a neuronal survivor. However, the molecular mechanisms …

Naturally Occurring I81N Mutation in Human Cytochrome c Regulates Both Inherent Peroxidase Activity and Interactions with Neuroglobin

Y Feng, XC Liu, L Li, SQ Gao, GB Wen, YW Lin - ACS omega, 2022 - ACS Publications
Human cytochrome c (h Cyt c) is a crucial heme protein and plays an indispensable role in
energy conversion and intrinsic apoptosis pathways. The sequence and structure of Cyt c …

Sesquiterpene lactones as emerging biomolecules to cease cancer by targeting apoptosis

CY Hsu, S Rajabi, M Hamzeloo-Moghadam… - Frontiers in …, 2024 - frontiersin.org
Apoptosis is a programmed cell death comprising two signaling cascades including the
intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy …

Mechanism of electron transfers mediated by cytochromes c and b5 in mitochondria and endoplasmic reticulum: classical and murburn perspectives

DA Gideon, V Nirusimhan, JC E… - Journal of …, 2022 - Taylor & Francis
We explore the mechanism of electron transfers mediated by cytochrome c, a soluble protein
involved in mitochondrial oxidative phosphorylation and cytochrome b 5, a microsomal …

Raman Imaging Reveals Accumulation of Hemoproteins in Plaques from Alzheimer's Diseased Tissues

Y El Khoury, A Schirer, C Patte-Mensah… - ACS Chemical …, 2021 - ACS Publications
Hemes have been suggested to play a central role in Alzheimer's disease since they show
high peroxidase reactivity when bound to amyloid β peptides, leading to the production of …

A 5′-flanking C/G pair at the core region enhances the recognition and binding of Kaiso to methylated DNA

B Thapa, NP Adhikari, PB Tiwari… - Journal of Chemical …, 2022 - ACS Publications
Methyl CpG binding proteins (MBPs) are transcription factors that recognize the methylated
CpG sites in DNA and mediate the DNA methylation signal into various downstream cellular …

Negative surface charges in neuroglobin modulate the interaction with cytochrome c

J Tejero - Biochemical and Biophysical Research …, 2020 - Elsevier
Neuroglobin is a heme protein present in the nervous system cells of mammals and other
organisms. Although cytoprotective effects of neuroglobin on neuronal damage have been …

Design and engineering of an artificial disulfide bond in human cytochrome c to regulate the protein structure and function

YY Li, Y Feng, L Yu, SS Long, SQ Gao… - … Systems Design & …, 2024 - pubs.rsc.org
Human cytochrome c (hCyt c) contains a covalently attached heme group with six-
coordination (Met/His) and plays vital biological functions, including electron transfer and …