Invasive candidiasis is an important fungal disease caused by Candida albicans and,
increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most …

Neonates are predisposed to infections during the perinatal period due to multiple
exposures and a relatively compromised immune system. The burden of disease attributed …

Abstract Background Invasive fungal diseases (IFDs) remain important causes of morbidity
and mortality. The consensus definitions of the Infectious Diseases Group of the European …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Clin Microbiol Infect 2012; 18 (Suppl. 7): 38–52 Abstract Invasive candidiasis (IC) is a
relatively common syndrome in neonates and children and is associated with significant …

BACKGROUND. Neonatal candidiasis is associated with substantial morbidity and mortality
rates. Neurodevelopmental follow-up data for a large multicenter cohort have not been …

Twenty percent of very-low-birth-weight (< 1500 g) preterm infants experience a serious
systemic infection, and despite advances in neonatal intensive care and antimicrobials …

Identifying neonates with sepsis is complicated by variability in clinical presentation. The
incidence of early onset sepsis (EOS) resulting from invasive group B streptococcal (GBS) …

Invasive fungal infections remain the leading causes of morbidity and mortality in neonates,
especially preterm and very low birth weight infants. Most invasive fungal infections are due …

Caspofungin is a parenteral antifungal that inhibits beta-1, 3-d-glucan synthesis. Although
licensed for adult use, the appropriate caspofungin dosing regimen in pediatric patients is …