Tetrazoles for biomedicine

EA Popova, RE Trifonov… - Russian Chemical …, 2019 - iopscience.iop.org
The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

Tetrazole derivatives as promising anticancer agents

EA Popova, AV Protas… - Anti-Cancer Agents in …, 2017 - ingentaconnect.com
Tetrazole cycle is a promising pharmacophore fragment frequently used in the development
of novel drugs. This moiety is a stable, practically non-metabolized bioisosteric analog of …

Microwave-assisted MgO NP catalyzed one-pot multicomponent synthesis of polysubstituted steroidal pyridines

A Ansari, A Ali, M Asif - New Journal of Chemistry, 2018 - pubs.rsc.org
The present study reports a highly efficient and green synthetic route for the synthesis of
steroidal pyridines. The synthetic methodology involves a microwave-assisted one-pot …

Tetrazoles: A multi-potent motif in drug design

Y Yuan, M Li, V Apostolopoulos, J Matsoukas… - European Journal of …, 2024 - Elsevier
The unique physicochemical properties and fascinating bioisosterism of tetrazole scaffolds
have received significant attention in medicinal chemistry. We report recent efforts using …

Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity

A Ansari, A Ali, N Khan, MS Umar, M Owais - Steroids, 2022 - Elsevier
Abstract Zinc oxide nanoparticles (ZnO NPs) were synthesized by a green method using
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …

Tetrazoles: Synthesis and biological activity

N Kaushik, N Kumar, A Kumar… - … , Endocrine & Metabolic …, 2018 - ingentaconnect.com
Background: In present decades, interest in tetrazole chemistry has been increasing rapidly
because of its broad range of biological applications, primarily due to the role played by …

Facile one-pot multicomponent synthesis and molecular docking studies of steroidal oxazole/thiazole derivatives with effective antimicrobial, antibiofilm and hemolytic …

A Ansari, A Ali, M Asif, MA Rauf, M Owais - Steroids, 2018 - Elsevier
A series of steroidal oxazole and thiazole derivatives have been synthesized employing
thiosemicarbazide/semicarbazide hydrochloride and ethyl 2-chloroacetoacetate with a …

DFT/B3LYP calculations, in vitro cytotoxicity and antioxidant activities of steroidal pyrimidines and their interaction with HSA using molecular docking and …

A Ali, M Asif, P Alam, MJ Alam, MA Sherwani… - Bioorganic …, 2017 - Elsevier
As a part of our continuing program on the synthesis of steroidal heterocycles, it has been
prepared a series of novel steroidal pyrimidine derivatives 4–6 via TMSCl, steroidal ketones …

Synthesis of charge transfer complex of chloranilic acid as acceptor with p-nitroaniline as donor: Crystallographic, UV–visible spectrophotometric and antimicrobial …

IM Khan, A Ahmad, L Miyan, M Ahmad… - Journal of Molecular …, 2017 - Elsevier
The charge transfer interaction between p-nitroaniline (PNA) and chloranilic (CAA) acid was
studied spectrophotometrically in methanol at different temperatures within the range 298 …

Synthesis of steroid bearing heterocyclic derivatives and biological activity. Review 2014-2020

AM Farhan, QK Alshamusi… - Journal of Physics …, 2021 - iopscience.iop.org
Steroidal building blocks have drawn research groups attention in many branches of
science and technology, such as pharmacological and medical fields, supramolecular …