The world is aging and, as the elderly population increases, age-related cognitive decline
emerges as a major concern. Neuroimaging techniques, such as functional magnetic …

As the global population ages, older decision makers will be required to take greater
responsibility for their own physical, psychological and financial well-being. With this in …

During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

Brain aging is characterized by considerable heterogeneity, including varying degrees of
dysfunction in specific brain systems, notably a medial temporal lobe memory system and a …

Given the key roles of the cerebellum in motor, cognitive, and affective operations and given
the decline of brain functions with aging, cerebellar circuitry is attracting the attention of the …

Impaired cognition is often overlooked in the clinical management of depression, despite its
association with poor psychosocial functioning and reduced clinical engagement. There is …

Aging is accompanied by profound changes in the brain's dopamine system that affect
cognitive function. Evidence of powerful individual differences in cognitive aging has …

Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

Highlights•Dopamine modulation declines in various brain regions during aging.•A
computational role of dopamine is neuronal gain control.•Aging neuronal gain control …

The cognitive deterioration associated with aging is accompanied by structural alterations
and loss of functionality of the frontostriatal dopamine system. The question arises how such …