Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …

The eukaryotic endoplasmic reticulum (ER) maintains protein homeostasis by eliminating
unwanted proteins through the evolutionarily conserved ER-associated degradation (ERAD) …

Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …

▪ Abstract A growing number of cellular regulatory mechanisms are being linked to protein
modification by the polypeptide ubiquitin. These include key transitions in the cell cycle …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Cellular functions are dictated by protein content and activity. There are numerous strategies
to regulate proteins varying from modulating gene expression to post‐translational …

Suppressor/Enhancer of Lin-12-like (Sel1L) is an adaptor protein for the E3 ligase
hydroxymethylglutaryl reductase degradation protein 1 (Hrd1) involved in endoplasmic …

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …

We show that ATE1-encoded Arg-transfer RNA transferase (R-transferase) of the N-end rule
pathway mediates N-terminal arginylation of multiple endoplasmic reticulum (ER)-residing …

Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum
(ER), polyubiquitylated by a protein complex termed the Hmg-CoA reductase degradation …