Applications of physiologically based absorption models in drug discovery and development
This article describes the use of physiologically based models of intestinal drug absorption
to guide the research and development of new drugs. Applications range from lead …
to guide the research and development of new drugs. Applications range from lead …
A pH-dilution method for estimation of biorelevant drug solubility along the gastrointestinal tract: application to physiologically based pharmacokinetic modeling
Y Gao, RA Carr, JK Spence, WW Wang… - Molecular …, 2010 - ACS Publications
Physiologically based pharmacokinetic (PBPK) modeling tools have become an integral part
of the modern drug discovery− development process. However, accurate PK prediction of …
of the modern drug discovery− development process. However, accurate PK prediction of …
The role of paracellular transport in the intestinal absorption and biopharmaceutical characterization of minoxidil
M Markovic, M Zur, S Garsiani, D Porat, S Cvijić… - Pharmaceutics, 2022 - mdpi.com
The purpose of this study was to evaluate mechanisms behind the intestinal permeability of
minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of …
minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of …
Physiologically based pharmacokinetic modeling in lead optimization. 1. Evaluation and adaptation of gastroplus to predict bioavailability of medchem series
When medicinal chemists need to improve bioavailability (% F) within a chemical series
during lead optimization, they synthesize new series members with systematically modified …
during lead optimization, they synthesize new series members with systematically modified …
PBPK modeling and simulation and therapeutic drug monitoring: Possible ways for antibiotic dose adjustment
Pharmacokinetics (PK) is a branch of pharmacology present and of vital importance for the
research and development (R&D) of new drugs, post-market monitoring, and continued …
research and development (R&D) of new drugs, post-market monitoring, and continued …
Predicting feasibility and characterizing performance of extended-release formulations using physiologically based pharmacokinetic modeling
J Brown, J Crison, P Timmins - Therapeutic Delivery, 2012 - Taylor & Francis
This review presents nine case studies where physiologically based pharmacokinetic
modeling has been used in the design and development of extended-release formulations …
modeling has been used in the design and development of extended-release formulations …
Physiologically based pharmacokinetic modeling in lead optimization. 2. Rational bioavailability design by global sensitivity analysis to identify properties affecting …
When medicinal chemists need to improve oral bioavailability (% F) during lead
optimization, they systematically modify compound properties mainly based on their own …
optimization, they systematically modify compound properties mainly based on their own …
A mechanistic approach for modeling oral drug delivery
N Pavurala, LEK Achenie - Computers & chemical engineering, 2013 - Elsevier
A drug release mechanism is combined with a Compartmental Absorption and Transit (CAT)
model within a pharmacokinetic framework for predicting orally administered drug release …
model within a pharmacokinetic framework for predicting orally administered drug release …
Computational Modeling of Drug Oral Bioavailability
LWR Fong, B Huang, R Chaudhari… - Oral Bioavailability and …, 2023 - Wiley Online Library
The oral bioavailability of a drug is a critical factor in determining its therapeutic efficacy.
Computational modeling approaches have emerged as valuable tools for predicting drug …
Computational modeling approaches have emerged as valuable tools for predicting drug …
Drug transport mechanisms across the intestinal epithelium
ALB Ungell - Oral Drug Absorption, 2016 - taylorfrancis.com
INTRODUCTION The most convenient and used route of administration of drugs for targets
within the systemic circulation is oral administration. To obtain a successful oral formulation …
within the systemic circulation is oral administration. To obtain a successful oral formulation …