Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats

HE Scharfman, NJ MacLusky - Neuropharmacology, 2014 - Elsevier
Many studies have described potent effects of BDNF, 17β-estradiol or androgen on
hippocampal synapses and their plasticity. Far less information is available about the …

Phthalates and neurotoxic effects on hippocampal network plasticity

MR Holahan, CA Smith - Neurotoxicology, 2015 - Elsevier
Phthalates are synthetically derived chemicals used as plasticizers in a variety of common
household products. They are not chemically bound to plastic polymers and over time, easily …

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation

JM Decker, L Krüger, A Sydow, S Zhao… - Acta neuropathologica …, 2015 - Springer
Introduction We used an inducible mouse model expressing the Tau repeat domain with the
pro-aggregant mutation ΔK280 to analyze presynaptic Tau pathology in the hippocampus …

Acute postnatal exposure to di (2-ethylhexyl) phthalate adversely impacts hippocampal development in the male rat

CA Smith, A Macdonald, MR Holahan - Neuroscience, 2011 - Elsevier
The distribution of CA3 hippocampal axonal terminal fields undergo a period of widespread
connectivity-based changes in the early postnatal stages of life. The purpose of the current …

Strain and sex differences in brain and behaviour of adult rats: Learning and memory, anxiety and volumetric estimates

RJ Keeley, C Bye, J Trow, RJ McDonald - Behavioural brain research, 2015 - Elsevier
Alterations in behaviour can arise through a number of factors, including strain and sex.
Here, we explored strain and sex differences between Long–Evans (LER) and Wistar (WR) …

Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to di (2-ethylhexyl) phthalate in male Long Evans rats

CA Smith, MR Holahan - PloS one, 2014 - journals.plos.org
Early developmental exposure to di (2-ethylhexyl) phthalate (DEHP) has been linked to a
variety of neurodevelopmental changes, particularly in rodents. The primary goal of this work …

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus

G Wiera, JW Mozrzymas - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Brain is continuously altered in response to experience and environmental changes. One of
the underlying mechanisms is synaptic plasticity, which is manifested by modification of …

Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes

RJ Keeley, J Trow, RJ McDonald - Neuroscience, 2015 - Elsevier
The use of recreational marijuana is widespread and frequently begins and persists through
adolescence. Some research has shown negative consequences of adolescent marijuana …

The roles of hippocampal microRNAs in response to acute postnatal exposure to di (2-ethylhexyl) phthalate in female and male rats

BE Luu, SR Green, CL Childers, MR Holahan… - Neurotoxicology, 2017 - Elsevier
Previous studies have shown that di (2-ethylhexyl) phthalate (DEHP) exposure impairs the
normal development of pre-and post-synaptic elements of the male, but not female, rat …

Remodeling of hippocampal mossy fibers is selectively induced seven days after the acquisition of a spatial but not a cued reference memory task

JL Rekart, CJ Sandoval, F Bermudez-Rattoni… - Learning & …, 2007 - learnmem.cshlp.org
Relating storage of specific information to a particular neuromorphological change is difficult
because behavioral performance factors are not readily disambiguated from underlying …