Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

Simple Summary Hypoxia-activated prodrugs (HAPs), selectively reduced by specific
oxidoreductases under hypoxic conditions, form cytotoxic agents damaging the local cancer …

The DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT), can confer
resistance to guanine O6-alkylating agents. Therefore, inhibition of resistant MGMT protein …

Hypoxia, a typical hallmark of numerous tumors, indicates poor infiltration of antitumor
lymphocytes, as well as facilitates the development, progression, and drug resistance of …

DNA interstrand crosslinks (ICLs) can be induced by numerous endogenous and
exogenous chemical agents with the capacity of covalently binding to two base sites in the …

Various mechanisms of drug resistance attenuate the effectiveness of cancer therapeutics,
including drug transport and DNA repair. The DNA repair protein O 6-methylguanine-DNA …

One-electron reductases that reduce nitro compounds in hypoxic human tumour cells are
poorly characterized, but are important for targeting hypoxia with nitroaromatic prodrugs …

1, 2-Bis (sulfonyl)-1-alkylhydrazines (BSHs) were conceived as more specific DNA guanine
O-6 methylating and chloroethylating agents lacking many of the undesirable toxicophores …

Aim: A hypoxia-activated combi-nitrosourea prodrug, N-(2-chloroethyl)-N′-2-(2-(4-
nitrobenzylcarbamate)-O 6-benzyl-9-guanine) ethyl-N-nitrosourea (NBGNU), was …

In the past years, many diazenyl compounds (ie diazenecarboxamides, diazeniumdiolate
prodrugs, diazenyl complexes etc.) have been prepared for the evaluation of their cytotoxic …