Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

A Markov, L Thangavelu, S Aravindhan… - Stem cell research & …, 2021 - Springer
Over recent years, mesenchymal stem/stromal cells (MSCs) and their potential biomedical
applications have received much attention from the global scientific community in an …

Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies

S Muthu, JV Korpershoek, EJ Novais… - Nature Reviews …, 2023 - nature.com
Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice

C Li, H Zhao, L Cheng, B Wang - Cell & Bioscience, 2021 - Springer
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

HY Kim, TJ Kim, L Kang, YJ Kim, MK Kang, J Kim… - Biomaterials, 2020 - Elsevier
Exosomes and extracellular nanovesicles (NV) derived from mesenchymal stem cells (MSC)
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …

Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration

W Li, Y Liu, P Zhang, Y Tang, M Zhou… - … applied materials & …, 2018 - ACS Publications
Exosomes, nanoscale extracellular vesicles functioning as cell-to-cell communicators, are
an emerging promising therapeutic in the field of bone tissue engineering. Here, we report …

Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612

L Ge, C Xun, W Li, S Jin, Z Liu, Y Zhuo, D Duan… - Journal of …, 2021 - Springer
Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such
as the induction of angiogenesis, particularly under hypoxic conditions. However, the …

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

AB Vasandan, S Jahnavi, C Shashank, P Prasad… - Scientific reports, 2016 - nature.com
Mesenchymal stem cells (MSCs) are speculated to act at macrophage-injury interfaces to
mediate efficient repair. To explore this facet in-depth this study evaluates the influence of …