Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of
several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid …

In addition to CD4+ T lymphocytes, cells of the myeloid lineage such as macrophages,
dendritic cells (DCs), and osteoclasts (OCs) are emerging as important target cells for HIV-1 …

SERINC5 is a multi-span transmembrane protein that is incorporated into HIV-1 particles in
producing cells and inhibits HIV-1 entry. Multiple retroviruses like HIV-1, equine infectious …

HIV infection of astrocytes leads to restricted gene expression and replication but abundant
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …

ABSTRACT A host cellular transmembrane protein, SERINC5, inhibits HIV-1 infectivity when
incorporated into progeny virions. Recent studies suggest that certain Envelope …

Background Nef performs multiple cellular activities that enhance HIV-1 pathogenesis. The
role of Nef-mediated down-regulation of the host restriction factor SERINC5 in HIV-1 …

Nef is an accessory protein unique to the primate HIV-1, HIV-2, and SIV lentiviruses. During
infection, Nef functions by interacting with multiple host proteins within infected cells to …

Human immunodeficiency virus-1 (HIV-1) is the major cause of acquired immunodeficiency
syndrome (AIDs) worldwide. In HIV-1 infection, innate immunity is the first defensive line for …

Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-
defined cellular activities. SER5 was recently described as a human immunodeficiency virus …

ABSTRACT Serine incorporator 5 (SERINC5) reduces the infectivity of progeny HIV-1 virions
by incorporating into the outer host-derived viral membrane during egress. To counter …