The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Diversity and dynamism in the cerebellum

CI De Zeeuw, SG Lisberger, JL Raymond - Nature neuroscience, 2021 - nature.com
The past several years have brought revelations and paradigm shifts in research on the
cerebellum. Historically viewed as a simple sensorimotor controller with homogeneous …

Optimal degrees of synaptic connectivity

A Litwin-Kumar, KD Harris, R Axel, H Sompolinsky… - Neuron, 2017 - cell.com
Synaptic connectivity varies widely across neuronal types. Cerebellar granule cells receive
five orders of magnitude fewer inputs than the Purkinje cells they innervate, and cerebellum …

Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis

H Fujita, T Kodama, S Du Lac - Elife, 2020 - elifesciences.org
The cerebellar vermis, long associated with axial motor control, has been implicated in a
surprising range of neuropsychiatric disorders and cognitive and affective functions …

Reward signals in the cerebellum: origins, targets, and functional implications

D Kostadinov, M Häusser - Neuron, 2022 - cell.com
The cerebellum has long been proposed to play a role in cognitive function, although this
has remained controversial. This idea has received renewed support with the recent …

Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control

X Wang, Z Liu, M Angelov, Z Feng, X Li, A Li… - Nature …, 2023 - nature.com
The brain generates predictive motor commands to control the spatiotemporal precision of
high-velocity movements. Yet, how the brain organizes automated internal feedback to …

Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations

EA Fleming, GD Field, MR Tadross, C Hull - Nature Neuroscience, 2024 - nature.com
The cerebellar cortex has a key role in generating predictive sensorimotor associations. To
do so, the granule cell layer is thought to establish unique sensorimotor representations for …

Computational principles of supervised learning in the cerebellum

JL Raymond, JF Medina - Annual review of neuroscience, 2018 - annualreviews.org
Supervised learning plays a key role in the operation of many biological and artificial neural
networks. Analysis of the computations underlying supervised learning is facilitated by the …

Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …