The COVID-19 pandemic has given the study of virus evolution and ecology new relevance. Although viruses were first identified more than a century ago, we likely know less about …
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …
E Shrock, E Fujimura, T Kula, RT Timms, IH Lee… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …
CR Consiglio, N Cotugno, F Sardh, C Pou, D Amodio… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …
Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …
EL Shrock, RT Timms, T Kula, EL Mena, AP West Jr… - Science, 2023 - science.org
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological …
JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross …
Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after …
P Brodin, MM Davis - Nature reviews immunology, 2017 - nature.com
The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled …