ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …

Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

One of the newly recognized types of cell death is ferroptosis which is related to the
accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a …

Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …

Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

Compounds that inhibit glutathione peroxidase 4 (GPX4) hold promise as cancer
therapeutics in their ability to induce a form of nonapoptotic cell death called ferroptosis. Our …

A number of studies have shown that aspirin, as commonly prescribed drug, prevents the
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …

Glutathione peroxidases (GPXs) are non-heme peroxidases catalyzing the reduction of
H2O2 or organic hydroperoxides to water or corresponding alcohols using glutathione …