Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Nearly all structures in our body experience mechanical forces. At a molecular scale, these
forces are detected by ion channels that function as mechanotransducers converting …

Mechanosensing is a ubiquitous process to translate external mechanical stimuli into
biological responses. Piezo1 ion channels are directly gated by mechanical forces and play …

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their
selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe …

Sensations of the internal state of the body play crucial roles in regulating the physiological
processes and maintaining homeostasis of an organism. However, our understanding of …

Abstract Purpose of Review: Atherosclerosis is the principal cause of cardiovascular
diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an …

PIEZO1 is a mechanosensitive channel widely presented in eukaryotic organisms. Although
the PIEZO family was discovered in 2010, main questions related to the molecular structure …

This Viewpoint, which accompanies a Special Issue focusing on membrane
mechanosensors, discusses unifying and unique features of both established and emerging …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Mechanotransduction is the process by which a mechanical force, such as touch, is
converted into an electrical signal. Transmembrane channel-like (TMC) proteins are an …