Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

The branched-chain amino acids are synthesized by plants, fungi and microorganisms, but
not by animals. Therefore, the enzymes of this pathway are potential target sites for the …

Drug resistance of pathogens has necessitated the identification of novel targets for
antibiotics. Thiamin (vitamin B1) is an essential cofactor for all organisms in its active form …

Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

The worldwide outbreak of severe acute respiratory syndrome (SARS) in 2003 had caused a
high rate of mortality. Main protease (M pro) of SARS-associated coronavirus (SARS-CoV) is …

Tuberculosis (TB) remains a major threat to human health. This due to the fact that current
drug treatments are less than optimal and the increasing occurrence of multi drug-resistant …

A photocatalytic C–H disulfuration of indolizines was developed, giving an approach to a
wide variety of indolizine-3-disulfides with good yields. Trisulfide dioxides were explored as …

Fe (Pc)-Catalyzed aerobic oxidation of thiols for the synthesis of disulfides has been
developed under mild reaction conditions. In addition, an aerobic oxidative cross …

Escherichia coli-mycobacterium shuttle vectors are important tools for gene expression and
gene replacement in mycobacteria. However, most of the currently available vectors are …

Acetohydroxyacid synthase (AHAS) catalyzes the first essential biosynthetic step of
branched-chain amino acids and is a biologically safe target against Mycobacterium …