Advances in our understanding of the metabolism and molecular functions of polyamines
and their alterations in cancer have led to resurgence in the interest of targeting polyamine …

Recent advances in omics technologies have led to unprecedented efforts characterizing
the molecular changes that underlie the development and progression of a wide array of …

Prostate cancer is the second most diagnosed cancer of men all over the world. In the last
few decades, new imaging techniques based on Magnetic Resonance Imaging (MRI) have …

Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from
the secreting cells. So far, biomarkers for pathological conditions have been mainly …

Background Prostate cancer tissues are inherently heterogeneous, which presents a
challenge for metabolic profiling using traditional bulk analysis methods that produce an …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Early detection of prostate cancer (PC) is largely carried out using assessment of prostate-
specific antigen (PSA) level; yet it cannot reliably discriminate between benign pathologies …

The objective of this study was to explore salivary metabolite biomarkers by profiling both
saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues …

Multiparametric MRI (mpMRI) is an imaging modality that combines anatomical MR imaging
with one or more functional MRI sequences. It has become a versatile tool for detecting and …

Metabolic reprogramming, as one of the characteristics of cancer, is associated with
tumorigenesis, growth, or migration, and the modulation of metabolic pathways has …