Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

Maintenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for
a wide variety of biological processes. We demonstrate that the N 6-adenosine …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome
transit along a given mRNA can influence nascent chain folding, but the extent to which …

Hydrogen sulfide-mediated signaling pathways regulate many physiological and
pathophysiological processes in mammalian and plant systems. The molecular mechanism …

Microbial pathogens deploy effector proteins to manipulate host cell innate immunity, often
using poorly understood unconventional secretion routes. Transfer RNA (tRNA) anticodon …

For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient …

S-adenosylmethionine (SAM) is the methyl donor for biological methylation modifications
that regulate protein and nucleic acid functions. Here, we show that methylation of a …