Roles and functions of HIV-1 Tat protein in the CNS: an overview
A Bagashev, BE Sawaya - Virology journal, 2013 - Springer
Nearly 50% of HIV-infected individuals suffer from some form of HIV-associated
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
neurocognitive disorders (HAND). HIV-1 Tat (a key HIV t rans a ctivator of t ranscription) …
HIV-1 Tat induces unfolded protein response and endoplasmic reticulum stress in astrocytes and causes neurotoxicity through glial fibrillary acidic protein (GFAP) …
Y Fan, JJ He - Journal of Biological Chemistry, 2016 - ASBMB
HIV-1 Tat is a major culprit for HIV/neuroAIDS. One of the consistent hallmarks of
HIV/neuroAIDS is reactive astrocytes or astrocytosis, characterized by increased cytoplasmic …
HIV/neuroAIDS is reactive astrocytes or astrocytosis, characterized by increased cytoplasmic …
Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein
P Rahimian, JJ He - Journal of neurovirology, 2016 - Springer
HIV-1 Tat is an indispensible transactivator for HIV gene transcription and replication. It has
been shown to exit cells as a free protein and enter neighboring cells or interact with surface …
been shown to exit cells as a free protein and enter neighboring cells or interact with surface …
HIV-1, methamphetamine and astrocyte glutamate regulation: combined excitotoxic implications for neuro-AIDS
IE Cisneros, A Ghorpade - Current HIV research, 2012 - ingentaconnect.com
Glutamate, the most abundant excitatory transmitter in the brain can lead to neurotoxicity
when not properly regulated. Excitotoxicity is a direct result of abnormal regulation of …
when not properly regulated. Excitotoxicity is a direct result of abnormal regulation of …
[HTML][HTML] HIV Nef expression down-modulated GFAP expression and altered glutamate uptake and release and proliferation in astrocytes
KM Wilson, JJ He - Aging and disease, 2023 - ncbi.nlm.nih.gov
HIV infection of astrocytes leads to restricted gene expression and replication but abundant
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …
expression of HIV early genes Tat, Nef and Rev. A great deal of neuroHIV research has so …
HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression
P Rahimian, JJ He - Journal of neuroinflammation, 2016 - Springer
Background Synaptodendritic damage is a pathological hallmark of HIV-associated
neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central …
neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central …
HIV tat impairs neurogenesis through functioning as a notch ligand and activation of notch signaling pathway
Alterations in adult neurogenesis have been noted in the brain of HIV-infected individuals
and are likely linked to HIV-associated neurocognitive deficits, including those in learning …
and are likely linked to HIV-associated neurocognitive deficits, including those in learning …
Use of stem cell extracellular vesicles as a “holistic” approach to CNS repair
H Branscome, S Paul, D Yin, N El-Hage… - Frontiers in Cell and …, 2020 - frontiersin.org
Neurodegeneration is a hallmark of many diseases and disorders of the central nervous
system (CNS). High levels of neuroinflammation are often associated with irreparable …
system (CNS). High levels of neuroinflammation are often associated with irreparable …
Activation of α7 nicotinic acetylcholine receptor ameliorates HIV-associated neurology and neuropathology
HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral
therapy are primarily manifested as impaired behaviours, glial activation/neuroinflammation …
therapy are primarily manifested as impaired behaviours, glial activation/neuroinflammation …