Human cardiac troponin complex. Structure and functions

IA Katrukha - Biochemistry (Moscow), 2013 - Springer
Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

[HTML][HTML] Intracellular pH sensors: design principles and functional significance

J Srivastava, DL Barber, MP Jacobson - Physiology, 2007 - journals.physiology.org
Abstract Changes in intracellular pH regulate many cell behaviors, including proliferation,
migration, and transformation. However, our understanding of how physiological changes in …

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes

FB Bedada, SSK Chan, SK Metzger, L Zhang, J Zhang… - Stem cell reports, 2014 - cell.com
There is no consensus in the stem cell field as to what constitutes the mature cardiac
myocyte. Thus, helping formalize a molecular signature for cardiac myocyte maturation …

Targeting the sarcomere to correct muscle function

PM Hwang, BD Sykes - Nature reviews Drug discovery, 2015 - nature.com
Various human diseases can disrupt the balance between muscle contraction and
relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by …

Cardiac myosin binding protein C phosphorylation is cardioprotective

S Sadayappan, H Osinska… - Proceedings of the …, 2006 - National Acad Sciences
Cardiac myosin binding protein C (cMyBP-C) has three phosphorylatable serines at its N
terminus (Ser-273, Ser-282, and Ser-302), and the residues' phosphorylation states may …

Muscle fatigue from the perspective of a single crossbridge

EP Debold, RH Fitts… - Medicine & Science …, 2016 - epublications.marquette.edu
The repeated intense stimulation of skeletal muscle rapidly decreases its force-and motion-
generating capacity. This type of fatigue can be temporally correlated with the accumulation …

Cardiac sarcomere signaling in health and disease

AA Martin, BR Thompson, D Hahn… - International journal of …, 2022 - mdpi.com
The cardiac sarcomere is a triumph of biological evolution wherein myriad contractile and
regulatory proteins assemble into a quasi-crystalline lattice to serve as the central point …

Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart

P Zhang, JA Kirk, W Ji, CG Dos Remedios, DA Kass… - Circulation, 2012 - Am Heart Assoc
Background—Human cardiac troponin I is known to be phosphorylated at multiple amino
acid residues by several kinases. Advances in mass spectrometry allow sensitive detection …

[HTML][HTML] 0.9% saline is neither normal nor physiological

H Li, S Sun, JQ Yap, J Chen, Q Qian - Journal of Zhejiang …, 2016 - ncbi.nlm.nih.gov
The purpose of this review is to objectively evaluate the biochemical and pathophysiological
properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion …

Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes

AB Stein, TA Jones, TJ Herron, SR Patel… - The Journal of …, 2011 - Am Soc Clin Investig
Histone H3 lysine 4 (H3K4me) methyltransferases and their cofactors are essential for
embryonic development and the establishment of gene expression patterns in a cell-specific …