Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …

Cardiovascular disease is the leading cause of death, accounting for 600,000 deaths each
year in the United States. In addition, heart failure accounts for 37% of health care spending …

Satellite cells, the quintessential skeletal muscle stem cells, reside in a specialized local
environment whose anatomy changes dynamically during tissue regeneration. The plasticity …

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an
unresolved problem in most forms of heart disease. In order to be successful in preventing …

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. Most
cardiovascular deaths are caused by ischaemic heart diseases such as myocardial …

Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with
outcome in patients. However, the basis for the development of both remains unclear. We …

Aims We investigated whether the pro-fibrotic matricellular protein osteopontin (OPN) is
associated with the enzymes involved in the extracellular synthesis of fibril-forming collagen …

Background and Objective The potential benefit of using hyaluronan (HA) in reconstructive
periodontal surgery is still a matter of debate. The aim of the present study was to evaluate …

Fibrillar collagens are the most abundant components of the extracellular matrix and provide
stability to connective tissues, such as bone, cartilage and skin. An imbalance in collagen …

Regenerative capacity of skeletal muscle declines with age, the cause of which remains
largely unknown. We investigated extracellular matrix (ECM) proteins and their regulators …