Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Induction of antigen-specific CD8+ T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with …

The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …

The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …

A main determinant of prolonged Trypanosoma brucei infection and transmission and
success of the parasite is the interplay between host acquired immunity and antigenic …

The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …

Plasmodium falciparum-infected erythrocytes (Pf IEs) present P. falciparum erythrocyte
membrane protein 1 proteins (Pf EMP1s) on the cell surface, via which they cytoadhere to …

The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and
host in shaping disease severity remains unclear. We explored the interaction between …