Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery
of useful antibodies for therapeutic or research purposes. We present a method for high …

Germinal center (GC) B cells evolve toward increased affinity by a Darwinian process that
has been studied primarily in genetically restricted, hapten-specific responses. We explored …

The presentation of protein antigens on the cell surface by major histocompatibility complex
(MHC) molecules coordinates vertebrate adaptive immune responses, thereby mediating …

Regulatory B cells that are functionally defined by their capacity to express IL-10 (B10 cells)
downregulate inflammation and autoimmunity. In studies using well-defined IL-10 reporter …

A contribution of epigenetic modifications to B cell tolerance has been proposed but not
directly tested. Here we report that deficiency of ten–eleven translocation (Tet) DNA …

The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells)
modulates both immune responses and autoimmune disease severity. However, the …

B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC),
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and …

We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the
germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B …

There is an unmet need for monoclonal antibodies (mAbs) for prevention or as adjunctive
treatment of herpes simplex virus (HSV) disease. Most vaccine and mAb efforts focus on …

The emergence of new variants of SARS-CoV-2 necessitates unremitting efforts to discover
novel therapeutic monoclonal antibodies (mAbs). Here, we report an extremely potent mAb …