The role of cell surface sialic acids for SARS-CoV-2 infection

XL Sun - Glycobiology, 2021 - academic.oup.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a new virus that has
higher contagious capacity than any other previous human coronaviruses (HCoVs) and …

Sphingolipid metabolism during Toll‐like receptor 4 (TLR4)‐mediated macrophage activation

A Olona, C Hateley, S Muralidharan… - British journal of …, 2021 - Wiley Online Library
Macrophage activation in response to stimulation of Toll‐like receptor 4 (TLR4) provides a
paradigm for investigating energy metabolism that regulates the inflammatory response …

The manifold roles of sphingolipids in viral infections

E Avota, J Bodem, J Chithelen, P Mandasari… - Frontiers in …, 2021 - frontiersin.org
Sphingolipids are essential components of eukaryotic cells. In this review, we want to
exemplarily illustrate what is known about the interactions of sphingolipids with various …

Glucocerebrosidase: functions in and beyond the lysosome

DEC Boer, J van Smeden, JA Bouwstra… - Journal of clinical …, 2020 - mdpi.com
Glucocerebrosidase (GCase) is a retaining β-glucosidase with acid pH optimum
metabolizing the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose …

Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens

M Sertbas, KO Ulgen - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

Oral and gut microbial carbohydrate-active enzymes landscape in health and disease

SO Onyango, J Juma, K De Paepe… - Frontiers in …, 2021 - frontiersin.org
Inter-individual variability in the microbial gene complement encoding for carbohydrate-
active enzymes (CAZymes) can profoundly regulate how the host interacts with diverse …

Lyso-glycosphingolipids: presence and consequences

M van Eijk, MJ Ferraz, RG Boot… - Essays in …, 2020 - portlandpress.com
Lyso-glycosphingolipids are generated in excess in glycosphingolipid storage disorders. In
the course of these pathologies glycosylated sphingolipid species accumulate within …

Enterohemorrhagic Escherichia coli and a Fresh View on Shiga Toxin-Binding Glycosphingolipids of Primary Human Kidney and Colon Epithelial Cells and Their …

J Detzner, G Pohlentz, J Müthing - International Journal of Molecular …, 2022 - mdpi.com
Enterohemorrhagic Escherichia coli (EHEC) are the human pathogenic subset of Shiga
toxin (Stx)-producing E. coli (STEC). EHEC are responsible for severe colon infections …

Cellular uptake pathways of nanoparticles: process of endocytosis and factors affecting their fate

S Varma, S Dey, D Palanisamy - Current Pharmaceutical …, 2022 - ingentaconnect.com
Background: Efficient and controlled internalization of NPs into the cells depends on their
physicochemical properties and dynamics of the plasma membrane. NPs-cell interaction is a …

Exploratory factor analysis determines latent factors in Guillain–Barré syndrome

S Omura, K Shimizu, M Kuwahara… - Scientific Reports, 2022 - nature.com
Exploratory factor analysis (EFA) has been developed as a powerful statistical procedure in
psychological research. EFA's purpose is to identify the nature and number of latent …