Whole-genome sequence assemblies are now available for seven different animals,
including nematode worms, mice and humans. Comparative genome analyses reveal a …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Signals through the Notch receptors are used throughout development to control cellular
fate choices. Loss-and gain-of-function studies revealed both the pleiotropic action of the …

The completion of whole genome sequencing projects has provided the genetic instructions
of life. However, whereas the identification of gene coding regions has progressed, the …

Cell-cell signaling mediated by the receptor Notch is used widely across the metazoans to
determine cell fate and regulate pattern formation. Notch signals via a conserved regulated …

Differential gene expression is the fundamental mechanism underlying animal development
and cell differentiation. However, it is a challenge to identify comprehensively and accurately …

The signals that determine activation and repression of specific genes in response to
appropriate stimuli are one of the most important, but least understood, types of information …

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses …

The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in
animal development. The fates of six vulval precursor cells are patterned through the action …

The segmentation gene network of Drosophila consists of maternal and zygotic factors that
generate, by transcriptional (cross-) regulation, expression patterns of increasing complexity …