A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

J Reed, S Bain, V Kanamarlapudi - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery

RWY Yeo, RC Lai, B Zhang, SS Tan, Y Yin… - Advanced drug delivery …, 2013 - Elsevier
Advances in biomedical research have generated an unprecedented number of potential
targets for therapeutic intervention to treat disease or delay disease progression …

Exosomes for drug delivery—a novel application for the mesenchymal stem cell

RC Lai, RWY Yeo, KH Tan, SK Lim - Biotechnology advances, 2013 - Elsevier
Exosomes are the most extensively characterized class of secreted membrane vesicles that
carry proteins and RNAs for intercellular communication. They are increasingly seen as …

Stem cell-based clinical trials for diabetes mellitus

E De Klerk, M Hebrok - Frontiers in endocrinology, 2021 - frontiersin.org
Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet
transplantation has been shown to be a promising therapy for patients with Type I Diabetes …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Fibroblasts and mesenchymal stem cells: Two sides of the same coin?

M Soundararajan, S Kannan - Journal of cellular physiology, 2018 - Wiley Online Library
Mesenchymal stem/stromal cells (MSCs) have gained considerable popularity owing to the
vast possibilities and lack of ethical constraints and risks normally associated with other …

Therapeutic potential of mesenchymal stem cells in regenerative medicine

DM Patel, J Shah, AS Srivastava - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self‐renew and
also exhibit multilineage differentiation into both mesenchymal and nonmesenchymal …

Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: a single-center, double-blinded, randomized, placebo …

L Zang, Y Li, H Hao, J Liu, Y Cheng, B Li, Y Yin… - Stem Cell Research & …, 2022 - Springer
Background To determine the efficacy and safety of umbilical cord-derived mesenchymal
stem cells (UC-MSCs) in Chinese adults with type 2 diabetes mellitus (T2DM). Methods In …