To accommodate daily recurring environmental changes, animals show cyclic variations in
behaviour and physiology, which include prominent behavioural states such as sleep–wake …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

INTRODUCTION Temporally consolidated behaviors such as sleep normally occur in
synchrony with endogenous circadian rhythms and both have been reported to contribute to …

BACKGROUND. The circadian clock is a fundamental and pervasive biological program that
coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to …

Wound healing, one of the most complex processes in the human body, involves the spatial
and temporal synchronization of a variety of cell types with distinct roles. Slow or nonhealing …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

The circadian clock controls many aspects of physiology, but it remains undescribed
whether extracellular vesicles (EVs), including exosomes, involved in cell-cell …

Collagen is the most abundant secreted protein in vertebrates and persists throughout life
without renewal. The permanency of collagen networks contrasts with both the continued …

Small extracellular vesicles (SEVs) offer a promising strategy for tissue regeneration, yet
their short lifetime at the injured tissue limits their efficacy. Here, we show that kinetics of …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …