Current status and perspectives of allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia

S Servais, Y Beguin, F Baron - Stem Cells Translational …, 2022 - academic.oup.com
As in younger patients, allogeneic stem cell transplantation (alloHSCT) offers the best
chance for durable remission in older patients (≥ 60 years) with acute myeloid leukemia …

[HTML][HTML] Choosing a reduced-intensity conditioning regimen for allogeneic stem cell transplantation, fludarabine/busulfan versus fludarabine melphalan: a systematic …

T Jain, F Alahdab, B Firwana, MB Sonbol… - Biology of Blood and …, 2019 - Elsevier
Fludarabine with busulfan (FB) or melphalan (FM) are 2 more commonly used reduced-
intensity conditioning (RIC) regimens for allogeneic stem cell transplantation (HCT). We …

Is there an optimal conditioning for older patients with AML receiving allogeneic hematopoietic cell transplantation?

SO Ciurea, P Kongtim, A Varma… - Blood, The Journal …, 2020 - ashpublications.org
The optimal conditioning regimen for older patients with acute myeloid leukemia (AML)
remains unclear. In this study, we compared outcomes of AML patients> 60 years of age …

Comparison of reduced intensity conditioning regimens used in patients undergoing hematopoietic stem cell transplantation for myelofibrosis

T Jain, KL Kunze, M Temkit, DK Partain… - Bone marrow …, 2019 - nature.com
The aim of this study is to compare clinical outcomes of patients who underwent allogeneic
stem cell transplantation (HCT) for myelofibrosis with reduced intensity conditioning (RIC) …

Busulfan and subsequent malignancy: An evidence‐based risk assessment

JR Long‐Boyle, DB Kohn, AJ Shah… - Pediatric Blood & …, 2024 - Wiley Online Library
Background The incidence of secondary malignancies associated with busulfan exposure is
considered low, but has been poorly characterized. Because this alkylating agent is …

[HTML][HTML] Comparison of conditioning with fludarabine/busulfan and fludarabine/melphalan in allogeneic transplantation recipients 50 years or older

K Kawamura, S Kako, S Mizuta, K Ishiyama… - Biology of Blood and …, 2017 - Elsevier
The optimal conditioning regimen for elderly patients undergoing allogeneic hematopoietic
stem cell transplantation (allo-HCT) remains unclear. We retrospectively analyzed 1607 …

Reduced intensity conditioning for acute myeloid leukemia using melphalan-vs busulfan-based regimens: a CIBMTR report

Z Zhou, R Nath, J Cerny, HL Wang, MJ Zhang… - Blood …, 2020 - ashpublications.org
There is a lack of large comparative study on the outcomes of reduced intensity conditioning
(RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and …

Comparison of reduced-intensity conditioning regimens in patients with acute lymphoblastic leukemia> 45 years undergoing allogeneic stem cell transplantation—a …

Z Peric, M Labopin, C Peczynski, E Polge… - Bone Marrow …, 2020 - nature.com
The optimal reduced-intensity conditioning (RIC) for patients with acute lymphoblastic
leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) …

[HTML][HTML] Favorable impact of allogeneic stem cell transplantation in patients with therapy-related myelodysplasia regardless of TP53 mutational status

I Aldoss, A Pham, SM Li, K Gendzekhadze… - …, 2017 - ncbi.nlm.nih.gov
Therapy-related myelodysplastic syndrome is a long-term complication of cancer treatment
in patients receiving cytotoxic therapy, characterized by high-risk genetics and poor …

[HTML][HTML] Fludarabine and melphalan compared with reduced doses of busulfan and fludarabine improve transplantation outcomes in older patients with …

B Oran, KW Ahn, C Fretham, A Beitinjaneh… - … and cellular therapy, 2021 - Elsevier
Reduced-intensity conditioning (RIC) regimens developed to extend the use of allogeneic
hematopoietic stem cell transplantation (HSCT) to older patients have resulted in …