Neddylation regulation of immune responses
H Mao, X Lin, Y Sun - Research, 2023 - spj.science.org
Neddylation plays a vital role in post-translational modification, intricately shaping the
regulation of diverse biological processes, including those related to cellular immune …
regulation of diverse biological processes, including those related to cellular immune …
Neddylation steers the fate of cellular receptors
JB Park, MY Lee, J Lee, GH Moon, SJ Kim… - … & Molecular Medicine, 2024 - nature.com
Cellular receptors regulate physiological responses by interacting with ligands, thus playing
a crucial role in intercellular communication. Receptors are categorized on the basis of their …
a crucial role in intercellular communication. Receptors are categorized on the basis of their …
Neddylation of insulin receptor substrate acts as a bona fide regulator of insulin signaling and its implications for cancer cell migration
Irregularities in insulin signaling have significantly increased the risk of various cancers, yet
the precise underlying mechanisms remain unclear. Within our study, we observed that …
the precise underlying mechanisms remain unclear. Within our study, we observed that …
Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
The ubiquitin-proteasome system (UPS) governs the degradation of proteins by
ubiquitinating their lysine residues. Our study focuses on lysine deserts-regions in proteins …
ubiquitinating their lysine residues. Our study focuses on lysine deserts-regions in proteins …
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses
L Sánchez-Alba, H Borràs-Gas, G Huang… - Trends in Biochemical …, 2024 - cell.com
Ubiquitin (Ub) and ubiquitin-like (UbL) modifications are critical regulators of multiple
cellular processes in eukaryotes. These modifications are dynamically controlled by …
cellular processes in eukaryotes. These modifications are dynamically controlled by …
Inhibition of neddylation disturbs zygotic genome activation through histone modification change and leads to early development arrest in mouse embryos
G Yang, Y Wang, S Hu, J Chen, L Chen, H Miao… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Post-translational modification and fine-tuned protein turnover are of great importance in
mammalian early embryo development. Apart from the classic protein degradation …
mammalian early embryo development. Apart from the classic protein degradation …
Inhibitory effect of a neddylation blockade on HTLV-1-infected T cells via modulation of NF-κB, AP-1, and Akt signaling
C Ishikawa, N Mori - Leukemia & Lymphoma, 2024 - Taylor & Francis
Adult T-cell leukemia (ATL), caused by HTLV-1, is the most lethal hematological malignancy.
NEDD8-activating enzyme (NAE) is a component of the NEDD8 conjunction pathway that …
NEDD8-activating enzyme (NAE) is a component of the NEDD8 conjunction pathway that …
Inhibition of neddylation causes early developmental arrestment in mouse embryo because of the zygotic genome activation failure
G Yang, S Hu, J Chen, L Chen, H Miao, N Li, H Luo… - 2023 - researchsquare.com
Background Maternal protein degradation in mammalian preimplantation embryos has yet to
be fully understood. One major pathway is the ubiquitin-proteasome system. Recently, new …
be fully understood. One major pathway is the ubiquitin-proteasome system. Recently, new …