Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

G protein–coupled receptors (GPCRs) represent the largest family of cell membrane
proteins, with> 800 GPCRs in humans alone, and recognize highly diverse ligands, ranging …

The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

Coat complexes coordinate cargo recognition through cargo adaptors with biogenesis of
transport carriers during integral membrane protein trafficking. Here, we combine …

Perturbations of the endolysosomal pathway have been suggested to play an important role
in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease …

Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of
cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 …

The highly conserved retromer complex controls the fate of hundreds of receptors that pass
through the endolysosomal system and is a central regulatory node for diverse metabolic …

The endolysosomal network consists of highly dynamic membrane-bound compartments
that control subcellular degradative and recycling processes. A conserved family of …

Endo‐lysosomal compartments exchange proteins by fusing, fissioning, and through
endosomal transport carriers. Thereby, they sort many plasma membrane receptors and …