All animals and plants dynamically attach and remove O-linked β-N-acetylglucosamine (O-
GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O …

The hexosamine biosynthesis pathway (HBP) is a relatively minor branch of glycolysis.
Fructose 6-phosphate is converted to glucosamine 6-phosphate, catalyzed by the first and …

The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

An increasing body of evidence points to a central regulatory role for glucose in mediating
cellular processes and expands the role of glucose well beyond its traditional role (s) in …

The post-translational modification of serine and threonine residues ofnucleocytoplasmic
proteins with 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc) is a reversible process …

O-GlcNAcylation, a dynamic nutrient and stress sensitive post-translational modification,
occurs on myriad proteins in the cell nucleus, cytoplasm and mitochondria. O-GlcNAcylation …

Similar to phosphorylation, O-GlcNAcylation (or simply GlcNAcylation) is an abundant,
dynamic, and inducible post-translational modification. In some cases, GlcNAcylation and …

The transcription factor NFκB is activated by phosphorylation and acetylation and plays
important roles in inflammatory and immune responses in the cell. Additionally …

O-linked β-N-acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification that,
analogous to phosphorylation, cycles on and off serine and/or threonine hydroxyl groups …

O-linked N-acetylglucosamine (O-GlcNAc) is an evolutionarily conserved modification of
nuclear pore proteins, signaling kinases, and transcription factors. The O-GlcNAc …