Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

P Aggarwal, JB Hall, CB McLeland… - Advanced drug delivery …, 2009 - Elsevier
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately
upon introduction of the materials into a physiological environment. The further biological …

Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors

ZP Van Acker, M Bretou, W Annaert - Molecular neurodegeneration, 2019 - Springer
Increasing evidence supports that cellular dysregulations in the degradative routes
contribute to the initiation and progression of neurodegenerative diseases, including …

The evolution of the protein corona around nanoparticles: a test study

M Lundqvist, J Stigler, T Cedervall, T Berggard… - ACS …, 2011 - ACS Publications
The importance of the protein corona formed around nanoparticles upon entering a
biological fluid has recently been highlighted. This corona is, when sufficiently long-lived …

Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles

T Cedervall, I Lynch, S Lindman… - Proceedings of the …, 2007 - National Acad Sciences
Due to their small size, nanoparticles have distinct properties compared with the bulk form of
the same materials. These properties are rapidly revolutionizing many areas of medicine …

[PDF][PDF] Detailed identification of plasma proteins adsorbed on copolymer nanoparticles

T Cedervall, I Lynch, M Foy, T Berggård… - Angewandte Chemie …, 2007 - academia.edu
Nanoparticles entering the bloodstream may initially bind highly abundant serum/plasma
proteins, such as human serum albumin (HSA). We show here that, as a result of its low …

Nanoparticle–protein corona complexes govern the biological fates and functions of nanoparticles

C Gunawan, M Lim, CP Marquis, R Amal - Journal of Materials …, 2014 - pubs.rsc.org
Upon contact with plasma or other protein-containing biological fluids, the surface of
nanoparticles is immediately decorated with proteins forming a biologically active protein …

The nanoparticle protein corona formed in human blood or human blood fractions

M Lundqvist, C Augustsson, M Lilja, K Lundkvist… - PloS one, 2017 - journals.plos.org
The protein corona formed around nanoparticles in protein-rich fluids plays an important role
for nanoparticle biocompatibility, as found in several studies during the last decade …

Differential plasma protein binding to metal oxide nanoparticles

ZJ Deng, G Mortimer, T Schiller, A Musumeci… - …, 2009 - iopscience.iop.org
Nanoparticles rapidly interact with the proteins present in biological fluids, such as blood.
The proteins that are adsorbed onto the surface potentially dictate the biokinetics of the …

Photoactivatable CaMKII induces synaptic plasticity in single synapses

ACE Shibata, HH Ueda, K Eto, M Onda, A Sato… - Nature …, 2021 - nature.com
Optogenetic approaches for studying neuronal functions have proven their utility in the
neurosciences. However, optogenetic tools capable of inducing synaptic plasticity at the …

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma

N Weygant, D Qu, R May, RM Tierney, WL Berry… - …, 2014 - pmc.ncbi.nlm.nih.gov
Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and the 8th
most common cancer overall in the US. RCC survival rates drop precipitously with regional …