This review focuses on discussing the main changes on the upcoming fourth edition of the
WHO Classification of Tumors of the Pituitary Gland emphasizing histopathological and …

Context Silent pituitary adenomas are anterior pituitary tumors with hormone synthesis but
without signs or symptoms of hormone hypersecretion. They have been increasingly …

Eur J Clin Invest 2011; 41 (10): 1133–1148 Abstract Background Aggressive pituitary
tumours are associated with substantial morbidity and mortality. Treatment options are often …

Human pituitary adenomas are the most common intracranial neoplasms. Approximately 5%
of them are familial adenomas. Patients with familial tumors carry germline mutations in …

Abstract Pituitary carcinoma occurs in~ 0.2% of resected pituitary tumours and carries a poor
prognosis (mean survival< 4 years), with standard chemotherapy regimens showing limited …

High-risk pituitary adenomas are aggressive. They show clinical and imaging features
similar to those of carcinomas, including infiltration of the surrounding brain structures, but …

MGMT promoter hypermethylation of aggressive pituitary adenomas and pituitary
carcinomas and low protein expression are implicated in improved response to treatment …

Pituitary neuroendocrine tumors (PitNETs) are the third most frequently diagnosed
intracranial tumors, with nonfunctioning PitNETs (nfPitNETs) accounting for 30% of all …

Purpose Knowledge of biological behavior is crucial for clinical management of functioning
pituitary macroadenomas. For recurrent cases unresponsive to standard treatment …

Pit-1 tumours are derived from neoplastic cells of either somatotroph, lactotroph or
thyrotroph cell lineages, but there are also distinct mixed tumours and plurihormonal …