Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Holocaust exposure induced intergenerational effects on FKBP5 methylation
R Yehuda, NP Daskalakis, LM Bierer, HN Bader… - Biological …, 2016 - Elsevier
Background The involvement of epigenetic mechanisms in intergenerational transmission of
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
stress effects has been demonstrated in animals but not in humans. Methods Cytosine …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Epigenetic pathways in human disease: the impact of DNA methylation on stress-related pathogenesis and current challenges in biomarker development
MA Argentieri, S Nagarajan, B Seddighzadeh… - …, 2017 - thelancet.com
HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …
the physiological impact of social and environmental stress, and have become a focal point …
The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Chronic Corticosterone Exposure Increases Expression and Decreases Deoxyribonucleic Acid Methylation of Fkbp5 in Mice
There is evidence for hypercortisolemia playing a role in the generation of psychiatric
symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis …
symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis …
FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior
C Touma, NC Gassen, L Herrmann, J Cheung-Flynn… - Biological …, 2011 - Elsevier
BACKGROUND: The Hsp90 cochaperone FK506 binding protein 5 (FKBP5) is an
established regulator of the glucocorticoid receptor (GR), and numerous genetic studies …
established regulator of the glucocorticoid receptor (GR), and numerous genetic studies …
Glucocorticoids, genes and brain function
GR Juszczak, AM Stankiewicz - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …
review of microarray reports revealed 88 genes whose transcription is consistently regulated …