Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

Epigallocatechin 3-gallate (EGCG), an abundant polyphenolic component derived from
green tea extract, possesses versatile bioactivities that can combat many diseases. During …

Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Parkinson's disease, the second most common neurodegenerative disorder worldwide, is
characterized by the accumulation of protein deposits in the dopaminergic neurons. These …

Neurological disorders are diseases of the central nervous system with progressive loss of
nervous tissue. One of the most difficult problems associated with neurological disorders is …

Abstract The aggregation of Alpha Synuclein (α-Syn) into fibrils is associated with the
pathology of several neurodegenerative diseases. Pathologic aggregates of α-Syn adopt …

Parkinson's disease (PD) and other synucleinopathies are characterized by the aggregation
and deposition of alpha-synuclein (α-syn) in brain cells, forming insoluble inclusions such as …

Parkinson's is the second most common neurodegenerative disease, with the number of
individuals susceptible due to increase as a result of increasing life expectancy and a …

The pathological features of PDD are represented by dopaminergic neuronal death and
intracellular α‐synuclein (α‐syn) aggregation. The interaction of iron accumulation with α …