Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and
subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis …

Nucleophosmin (NPM1) is an abundant, ubiquitously expressed protein mainly localized at
nucleoli but continuously shuttling between nucleus and cytoplasm. NPM1 plays a role in …

When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs
associate with chromosomes, establishing a perichromosomal compartment coating the …

Nucleophosmin (NPM1) is a multifunctional phospho-protein with critical roles in ribosome
biogenesis, tumor suppression, and nucleolar stress response. Here we show that the N …

Isoniazid is used either alone or in combination with other drugs for the treatment of
tuberculosis. It is also used for the prevention of tuberculosis. Chronic treatment of Isoniazid …

Neural crest migration is critical to its physiological function. Mechanisms controlling
mammalian neural crest migration are comparatively unknown, due to difficulties accessing …

A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein
(sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP …

The dual-specificity phosphatase 3 (DUSP3), an atypical protein tyrosine phosphatase
(PTP), regulates cell cycle checkpoints and DNA repair pathways under conditions of …

Oxidative stress is a leading cause of endothelial dysfunction. The p38 MAPK pathway plays
a determinant role in allowing cells to cope with oxidative stress and is tightly regulated by a …

Abstract Nucleophosmin (NPM1) is the 46th most abundant human protein with many
functions whose dysregulation leads to various cancers. Pentameric NPM1 resides in the …