Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders

TR Butler, AN Karkhanis, SR Jones… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Individuals diagnosed with anxiety‐related illnesses are at increased risk of developing
alcoholism, exhibit a telescoped progression of this disease and fare worse in recovery …

Sex differences in stress-induced alcohol intake: a review of preclinical studies focused on amygdala and inflammatory pathways

YS Mineur, V Garcia-Rivas, MA Thomas, AR Soares… - …, 2022 - Springer
Clinical studies suggest that women are more likely than men to relapse to alcohol drinking
in response to stress; however, the mechanisms underlying this sex difference are not well …

Ethanol-induced suppression of G protein–gated inwardly rectifying K+–dependent signaling in the basal amygdala

EMF de Velasco, ME Tipps, B Haider, A Souders… - Biological …, 2023 - Elsevier
Background The basolateral amygdala (BLA) regulates mood and associative learning and
has been linked to the development and persistence of alcohol use disorder. The GABA BR …

Enhanced ventral hippocampal synaptic transmission and impaired synaptic plasticity in a rodent model of alcohol addiction vulnerability

AG Almonte, SE Ewin, MI Mauterer, JW Morgan… - Scientific reports, 2017 - nature.com
It has long been appreciated that adolescence represents a uniquely vulnerable period
when chronic exposure to stressors can precipitate the onset of a broad spectrum of …

The lateral intercalated cell mass of the amygdala is activated during social buffering of conditioned fear responses in male rats

S Minami, Y Kiyokawa, Y Takeuchi - Behavioural Brain Research, 2019 - Elsevier
The presence of an affiliative conspecific reduces stress responses to a wide variety of
stimuli. This phenomenon is termed “social buffering”. We previously found that the …

Female-specific decreases in alcohol binge-like drinking resulting from GABAA receptor delta-subunit knockdown in the VTA

LM Darnieder, LC Melón, T Do, NL Walton… - Scientific reports, 2019 - nature.com
Binge drinking is short-term drinking that achieves blood alcohol levels of 0.08 g/dl or above.
It exhibits well-established sex differences in GABAergic inhibitory neurotransmission …

The antihypertensive drug pindolol attenuates long‐term but not short‐term binge‐like ethanol consumption in mice

OL Patkar, A Belmer, JY Holgate, JR Tarren… - Addiction …, 2017 - Wiley Online Library
Alcohol dependence is a debilitating disorder with current therapies displaying limited
efficacy and/or compliance. Consequently, there is a critical need for improved …

Behavioral and neurophysiological evidence that lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the acquisition and extinction of …

MJ Skelly, AM Chappell, OJ Ariwodola… - Neurobiology of learning …, 2016 - Elsevier
The lateral/basolateral amygdala (BLA) is crucial to the acquisition and extinction of
Pavlovian fear conditioning, and synaptic plasticity in this region is considered to be a neural …

Bidirectional control of alcohol-drinking behaviors through locus coeruleus optoactivation

AL Deal, CE Bass, VP Grinevich, O Delbono, KD Bonin… - Neuroscience, 2020 - Elsevier
The relationship between stress and alcohol-drinking behaviors has been intensively
explored; however, neuronal substrates and neurotransmitter dynamics responsible for a …

Chronic ethanol exposure potentiates cholinergic neurotransmission in the basolateral amygdala

SE Sizer, BC Parrish, BA McCool - Neuroscience, 2021 - Elsevier
Chronic intermittent ethanol (CIE) exposure dysregulates glutamatergic and GABAergic
neurotransmission, facilitating basolateral amygdala (BLA) pyramidal neuron …