Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …

Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized
by high cellular heterogeneity. The diversity of cell types and the interplay between tumor …

Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and
an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA …

The clinical relevance of immune landscape intratumoural heterogeneity (immune-ITH) and
its role in tumour evolution remain largely unexplored. Here, we uncover significant spatial …

Background: Reversal of CD8 T-cell exhaustion was considered a major antitumor
mechanism of anti-programmed cell death-1 (PD-1)/anti-programmed death ligand-1 (PD …

Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within
nonlymphoid tissue. They share structural and functional characteristics with secondary …

Hepatocarcinogenesis involves complex genetic and cellular dysregulations which drive the
formation of hepatocellular carcinoma (HCC), the predominant form of primary liver cancer …

Over the past decade, immune checkpoint blockade (ICB) therapy has revolutionized the
outlook for oncology with significant and sustained improvement in the overall patient …

Background A major current challenge is to exploit tertiary lymphoid structures (TLSs) to
promote the lymphocyte infiltration, activation and differentiation by tumor antigens to …