Macrophage autophagy and bacterial infections

A Bah, I Vergne - Frontiers in immunology, 2017 - frontiersin.org
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in
bacterial infections. One of the most studied is probably xenophagy, the selective capture …

Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection

A Nisa, FC Kipper, D Panigrahy… - … of Physiology-Cell …, 2022 - journals.physiology.org
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells

A Romagnoli, MP Etna, E Giacomini, M Pardini… - Autophagy, 2012 - Taylor & Francis
Emerging evidence points to an important role of autophagy in the immune response
mediated by dendritic cells (DC) against Mycobacterium tuberculosis (Mtb). Since current …

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis

THM Ottenhoff, RH Dass, N Yang, MM Zhang… - 2012 - journals.plos.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains the leading cause
of mortality from a single infectious agent. Each year around 9 million individuals newly …

Risk of tuberculosis reactivation in patients with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis receiving non‐anti‐TNF‐targeted biologics

F Cantini, C Nannini, L Niccoli, L Petrone… - Mediators of …, 2017 - Wiley Online Library
Tuberculosis (TB) still represents an important issue for public health in underdeveloped
countries, but the use of antitumor necrosis factor agents (anti‐TNF) for the treatment of …

[HTML][HTML] MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

CK Bullen, AK Singh, S Krug, S Lun, P Thakur… - JCI insight, 2023 - ncbi.nlm.nih.gov
Host cytosolic sensing of Mycobacterium tuberculosis (M. tuberculosis) RNA by the RIG-I–
like receptor (RLR) family perturbs innate immune control within macrophages; however, a …

Host directed therapies for tuberculosis: futures strategies for an ancient disease

I Palucci, G Delogu - Chemotherapy, 2018 - karger.com
The emergence and spread of drug-resistant strains of Mycobacterium tuberculosis is
worsening the global threat of tuberculosis (TB). There is a need and urgency for the …

The Macrophage Response to Mycobacterium tuberculosis and Opportunities for Autophagy Inducing Nanomedicines for Tuberculosis Therapy

RE Maphasa, M Meyer, A Dube - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
The major causative agent of tuberculosis (TB), ie, Mycobacterium tuberculosis (Mtb), has
developed mechanisms to evade host defense responses and persist within host cells for …

The ubiquitin ligase TRIM32 promotes the autophagic response to Mycobacterium tuberculosis infection in macrophages

A Romagnoli, M Di Rienzo, E Petruccioli, C Fusco… - Cell Death & …, 2023 - nature.com
Mycobacterium tuberculosis (Mtb) is known to evade host immune responses and persist in
macrophages for long periods. A mechanism that the host uses to combat Mtb is xenophagy …

Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection

K Mohareer, S Asalla, S Banerjee - Tuberculosis, 2018 - Elsevier
Tuberculosis (TB) continues to be the leading cause of death by any single infectious agent,
accounting for around 1.7 million annual deaths globally, despite several interventions and …