Leydig cells, thyroid hormones and steroidogenesis. - Abstract - Europe PMC Sign in | Create
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Male reproduction is governed by the classical hypothalamo-hypophyseal testicular axis:
Hypothalamic gonadotropin releasing hormone (GnRH), pituitary luteinizing hormone (LH) …

Thyroid hormones are important for growth and development of many tissues. Altered
thyroid hormone status causes testicular abnormalities. For instance, juvenile …

Transgenerational carcinogenesis refers to transmission of cancer risk to the untreated
progeny of parents exposed to carcinogens before mating. Accumulated evidence suggests …

The effect of T3 on basal and LH mediated synthesis and secretion of testosterone and
oestradiol by puberal rat Leydig cells was studied in vitro. Percoll gradient purified Leydig …

Thyroid hormones are involved in the development and function of the male reproductive
system, but their effects on the prostate have been poorly studied. This work reviews studies …

BACKGROUND Infertility associated with congenital and early childhood hypothyroidism is
an important reproductive health problem in men. Nevertheless, the exact mechanism …

We have previously demonstrated that neonatal and transient neonatal hypothyroidism
modulates Leydig, Sertoli, and germ cell numbers, sex steroids and androgen binding …

Thyroxine (T 4) promotes cell proliferation and tumor growth in prostate cancer models, but it
is unknown if the increase in the triiodothyronine (T 3)/T 4 ratio could attenuate prostate …

The aim of this study was to characterize the type of 5′-deiodinase activity in the prostate of
pubescent rats (7–8 weeks), to establish its distribution in the lobes (ventral, dorsolateral …