Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects
beyond cholesterol reduction, including anticancer activity. This review presents the effects …

The ABCA1 protein mediates the transfer of cellular cholesterol across the plasma
membrane to apolipoprotein AI. Loss-of-function mutations in the ABCA1 gene induce …

Cancer chemoprevention is a strategy taken to retard, regress, or resist the multistep
process of carcinogenesis, including the blockage of its vital morphogenetic milestones viz …

Cancer risk reduction using pharmacological means is an attractive modern preventive
approach that supplements the classical behavioural prevention recommendations …

Statins, HMG‐CoA reductase inhibitors could be associated with the risk reduction of
colorectal cancer. We previously demonstrated that simvastatin inhibits NF‐κB signaling in …

Statins are HMG-CoA reductase inhibitors with important cholesterol-lowering properties.
The introduction of these agents in clinical medicine has had a major impact and has …

Recent reports have suggested that statins induce cell death in certain epithelial cancers
and that patients taking statins to reduce cholesterol levels possess lower cancer incidence …

Chinese red yeast rice (RYR) is a food herb made by fermenting Monascus purpureus Went
yeast with white rice. RYR contains a mixture of monacolins, one of which—monacolin K …

A growing body of experimental evidence suggests the therapeutic potential of diosgenin, a
furostanol saponin against several cancers. However, precise molecular and cellular …